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Personal Narrative: The Special Movement In American History - Pharmacodynamics. Methacarbamol is a skeletal muscle relaxant with an unknown mechanism of action. 5 Methacarbamol has been shown to block spinal polysynaptic reflexes, decrease nerve transmission in spinal and supraspinal polysynaptic pathways, and prolong the refractory period of muscle cells. 5,4 Methocarbamol does not act as a local anesthetic upon injection. 4 In animal studies. A study of patients with liver cirrhosis and chronic hepatitis C who presented with frequent muscle cramps (≥ 3 cramps per week) was conducted. Half of these patients received methocarbamol and the other half received placebo. This was done through equal randomization. This study aimed to evaluate the efficacy and safety of methocarbamol as a novel therapy in controlling muscle cramps in cirrhotic patients. Patients and methods This study was carried on patients with liver cirrhosis in addition to chronic hepatitis C who presented with frequent muscle cramps (≥three cramps per week). Chicago Police Theory

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